Are There Any Side Effects of Joint Injections?

Are There Any Side Effects of Joint Injections?

When performed by experienced clinicians using ultrasound guidance, joint injections are considered safe and well-tolerated. Most side effects are mild and temporary.

Common Side Effects (Usually Short-Lived)

Some patients may experience:

  • Mild pain or soreness at the injection site
  • Temporary swelling or stiffness
  • A feeling of warmth in the joint
  • Bruising around the injection area

These effects usually settle within 24–48 hours. 

Side Effects Specific to Cortisone Injections

Cortisone injections may occasionally cause:

  • Temporary increase in pain for 24–48 hours (“steroid flare”)
  • Facial flushing for a short period
  • Temporary rise in blood sugar levels (especially in people with diabetes)
  • Skin lightening or thinning at the injection site (rare)

Repeated cortisone injections into the same joint are spaced carefully to reduce potential risks. To learn more about the side effects of cortisone injections, read our blog here.

Side Effects Specific to Hyaluronic Acid Injections

Hyaluronic acid injections are generally well tolerated. Possible side effects include:

  • Mild joint swelling or stiffness
  • Temporary discomfort during movement
  • A feeling of fullness in the joint

Serious reactions are rare.

Can Joint Injections Be Repeated?

Yes, joint injections can be repeated if appropriate. The timing and frequency depend on the type of injection and your clinical response. Your specialist at Alton Pain Clinic will advise on safe and suitable intervals.

Book an Appointment at Alton Pain Clinic

If joint pain is limiting your movement or comfort, our experienced clinicians can help.

Frequently Asked Questions

Do joint injections have side effects?

Most joint injections have mild and temporary side effects, especially when performed under ultrasound guidance by experienced clinicians.

Common side effects include mild soreness, temporary swelling, stiffness, or bruising around the injection site. These usually settle within 24–48 hours.

Yes. Ultrasound guidance improves accuracy, reduces the risk of injury to nearby structures, and enhances overall safety.

Most patients can walk immediately and return to light activities the same day. Strenuous activity should be avoided for 24–48 hours.